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斗牛棋牌SHENGCHANCHANGJIA: SUZHOUDONGRUIZHIYAOYOUXIANGONGSI

PIZHUNWENHAO:GUOYAOZHUNZIH20100129

斗牛棋牌YAOPINGUIGE:0.5mg*14PIAN

YAOPINJIAGE:¥0YUAN

藥師來電

恩替卡韋分散片的說明書

【TONGYONGMING】ENTIKAWEIFENSANPIAN

【CHENGFEN】ENTIKAWEIFENSANPIANZHUYAOCHENGFENWEI:ENTIKAWEI。HUAXUEMINGCHENG:2-ANJI-9-[(1S,3R,4S)-4-QIANJI-3-QIANJIAJI-2-YAJIAJIHUANWUJI]-1,9-ERQING-6H-PIAOLING-6-TONGYISHUIHEWU。

【XINGZHUANG】ENTIKAWEIFENSANPIANWEIBAISEHUOLEIBAISEPIAN。

斗牛棋牌【SHIYINGZHENG】BENPINWEIBAISEHUOLEIBAISEPIAN。

斗牛棋牌【YONGFAYONGLIANG】HUANZHEYINGZAIYOUJINGYANDEYISHENGZHIDAOXIAFUYONGENTIKAWEIFENSANPIAN 。TUIJIANJILIANGCHENGRENHE16SUIJIYISHANGDEQINGSHAONIANKOUFUENTIKAWEIFENSANPIAN ,MEITIANYICI,MEICI0.5mg。LAMIFUDINGZHILIAOSHIDEFASHENGBINGDUXUEZHENGHUOCHUXIANLAMIFUDINGNAIYAOTUBIANDEHUANZHEWEIMEITIANYICI,MEICI1mg(0.5mgLIANGPIAN)。ENTIKAWEIFENSANPIAN YINGKONGFUFUYONG(CANQIANHUOCANHOUZHISHAO2XIAOSHI)。SHENGONGNENGBUQUANZAISHENGONGNENGBUQUANDEHUANZHEZHONG,ENTIKAWEIDEBIAOXIANKOUFUQINGCHULVSUIJIGANQINGCHULVDEJIANGDIERJIANGDI(CANJIANYAODAIDONGLIXUE,TESHURENQUN)。JIGANQINGCHULV<50ml/FENZHONGDEHUANZHE(BAOKUOJIESHOUXUEYETOUXIHUOCAPDZHILIAODEHUANZHE)YINGDIAOZHENGYONGYAOJILIANG。JIANBIAO1。BIAO1:SHENGONGNENGBUQUANHUANZHEENTIKAWEITUIJIANYONGYAOJIANGEDIAOZHENGJIGANQINGCHULV(ml/min) TONGCHANGJILIANG(0.5mg) LAMIFUDINGZHILIAOSHIXIAO(1.0mg)≥50 MEIRIYICI,MEICI0.5mg MEIRIYICI,MEICI1mg30DAO<50 MEI48XIAOSHIYICI,MEICI0.5mg MEI48XIAOSHIYICI,MEICI1mg10DAO<30 MEI72XIAOSHIYICI,MEICI0.5mg MEI72XIAOSHIYICI,MEICI1mg<10HUOXUEYETOUXIHUOCAPD MEI5-7RIYICI,MEICI0.5mg MEI5-7RIYICI,MEICI1mgGANGONGNENGBUQUANGANGONGNENGBUQUANHUANZHEWUXUDIAOZHENGYONGYAOJILIANG。ZHILIAOQIGUANYUENTIKAWEIFENSANPIAN DEZUIJIAZHILIAOSHIJIAN,YIJIYUCHANGQIDEZHILIAOJIEGUODEGUANXI,RUGANYINGHUA、GANLIUDENG,MUQIANSHANGWEIMINGLE。

【YAOLIDULI】

【藥代動力學】吸收健康受試者口服用藥后,恩替卡韋分散片被迅速吸收,0.5到1.5小時達到峰濃度(Cmax)。每天給藥一次,6-10天后可達穩態,累積量約為兩倍。食物對口服吸收的影響進食標準高脂餐或低脂餐的同時口服0.5mg恩替卡韋分散片會導致藥物吸收的輕微延遲(從原來的0.75小時變為1.0-1.5小時),Cmax降低44-46%,藥時曲線下面積(AUC)降低18-20%。因此,恩替卡韋分散片應空腹服用(餐前或餐后至少2小時)。分布藥代動力學資料表明,其表觀分布容積超過全身液體量,這說明恩替卡韋分散片廣泛分布于各組織。體外實驗表明恩替卡韋分散片與人血漿蛋白結合率為13%。代謝和清除在給人和大鼠服用14C標記的恩替卡韋后,未觀察到恩替卡韋分散片的氧化或乙酰化代謝物,但觀察到少量Ⅱ期代謝產物葡萄糖醛酸甙結合物和硫酸結合物。恩替卡韋不是細胞色素P450(CYP450)酶系統的底物、抑制劑或誘導劑。在達到血漿峰濃度后,血藥濃度以雙指數方式下降,達到終末清除半衰期約需128-149小時。藥物累積指數約為每天一次給藥劑量的2倍,這表明其有效累積半衰期約為24小時。恩替卡韋分散片主要以原形通過腎臟清除,清除率為給藥量的62-73%。腎清除率為360-471ml/min,且不依賴于給藥劑量,這表明恩替卡韋同時通過腎小球濾過和網狀小管分泌。特殊人群性別:恩替卡韋分散片的藥代動力學不因性別的不同而改變。種族:恩替卡韋分散片的藥代動力學不因種族的不同而改變。老年人:一項評價年齡與恩替卡韋分散片藥代動力學關系的研究(口服恩替卡韋分散片1mg)顯示老年人的AUC較健康年輕人升高29.3%,這很可能是由于個體腎功能的差異所造成的。老年人的用藥劑量參看腎功能不全者的劑量調節。腎功能不全在不同程度腎功能不全的患者(無慢性乙型肝炎病毒感染),包括使用血液透析或持續性便攜式腹膜透析(CAPD)治療的患者中,單次給藥1mg恩替卡韋分散片后的藥代動力學結果顯示清除率隨肌酐清除率的降低而下降。血液透析前2小時單次給藥1mg恩替卡韋分散片,血液透析4小時能清除約給藥劑量的13%,CAPD治療7天僅能清除給藥劑量的0.3%。恩替卡韋應在血液透析后給藥。肝功能不全在中度和重度肝功能不全(Child-Pugh分級B或C)的患者(不包括慢性乙肝病毒感染患者)中,研究了單次給藥1mg后恩替卡韋的藥代動力學情況,肝功能不全的患者與健康對照患者的恩替卡韋的藥代動力學情況相似。因此,無需再肝功能不全患者中調節恩替卡韋的給藥劑量。肝移植后目前尚不清楚恩替卡韋分散片在肝移植患者中的安全性和有效性。一個小型的研究中,在使用穩定劑量的環孢酶素A(n=5)或他克莫司(n=4)治療HBV感染肝移植患者中,由于腎功能的改變,恩替卡韋分散片在體內的總量約為腎功能正常的健康人的兩倍。腎功能的改變是導致恩替卡韋分散片在這些患者中濃度增加的原因。恩替卡韋分散片與環孢酶素A或他克莫司之間的藥物動力學的相互作用尚未被正式評價。對于曾經或正在接受可能影響腎功能的免疫抑制劑,如:環孢酶素A或他克莫司,治療的肝移植受體患者,接受恩替卡韋治療前和治療中,應該嚴密監測腎功能(見[用法用量]項下腎功能不全患者的劑量調整)。兒童用藥尚無兒童使用該藥的藥代動力學數據。

【BULIANGFANYING】DUIBULIANGFANYINGDEPINGJIAJIYU4XIANGQUANQIUDELINCHUANGSHIYAN:A1463014,A1463022,A1463026,A1463027YIJI3XIANGZAIZHONGGUOJINXINGDELINCHUANGSHIYAN(A1463012,A1463023,A1463056)。ZAIZHE7XIANGYANJIUZHONG,GONGYOU2596WEIMANXINGYIGANHUANZHERUXUAN。ZAIYULAMIFUDINGDUIZHAODEYANJIUZHONG,ENTIKAWEIYULAMIFUDINGDEBULIANGSHIJIANHESHIYANSHIJIANCHAYICHANGQINGKUANGXIANGSI。ZAIGUOWAIJINXINGDEYANJIUZHONG,BENPINZUICHANGJIANDEBULIANGSHIJIANYOU:TOUTONG、PILAO、XUANYUN、EXIN。LAMIFUDINGZHILIAODEHUANZHEPUBIANCHUXIANDEBULIANGSHIJIANYOU:TOUTONG、PILAO、XUANYUN。ZAIZHE4XIANGYANJIUZHONG,FENBIEYOU1%DEENTIKAWEIZHILIAODEHUANZHEHE4%LAMIFUDINGZHILIAODEHUANZHEYOUYUBULIANGSHIJIANHESHIYANSHIJIANCEZHIBIAOYICHANGERTUICHUYANJIU。GUOWAILINCHUANGBULIANGSHIJIANBIAO2(JIANXIANGXISHUOMINGSHU)BIJIAOLEZAI4XIANGLINCHUANGYANJIUZHONGENTIKAWEIHELAMIFUDINGDEBUTONG。QIZHONGXUANZELEZHONGDAOZHONGDUBULIANGSHIJIANHEZHILIAOGUOCHENGZHONGFASHENGDEZHISHAOYOUKENENGYUZHILIAOXIANGGUANDELINCHUANGBULIANGSHIJIANZUOWEIBIJIAODEZHIBIAO。GUOWAISHIYANSHIJIANCEZHIBIAOYICHANGBIAO3(JIANXIANGXISHUOMINGSHU)LIECHUSIXIANGLINCHUANGSHIYANZHONGSHIYONGENTIKAWEIHELAMIFUDINGZHILIAOHOU,SHIYANSHIJIANCHAYICHANGDEFASHENGPINLV。ZAIZHEXIEYANJIUZHONG,SHIYONGENTIKAWEIDEHUANZHEZAIZHILIAOGUOCHENGZHONGFASHENGALTZENGGAOZHI10BEIDEZHENGCHANGZHISHANGXIANHEJIXIANZHIDE2BEISHI,TONGCHANGJIXUYONGYAOYIDUANSHIJIAN,ALTKEHUIFUZHENGCHANG;ZAICIZHIQIANHUOTONGSHIBANSUIYOUBINGDUZAILIANG2GEDUISHUZHIDEXIAJIANG。GUZAIYONGYAOQIJIAN,XUDINGQIJIANCEGANGONGNENG。TINGZHIZHILIAOHOUDEGANYANJIAJU(JIAN[JINGGAO])GANYANJIXINGJIAJUHUOALTFURANDEDINGYIWEI:ALTDAYU10BEIDEZHENGCHANGZHISHANGXIANHEDAYU2BEIHUANZHEDECANKAOSHUIPING(JIXIANZHIHUOTINGYAOSHIZUIHOUYICIJIANCEZHIJIANDEZUIXIAOZHI)。SUOYOUTINGZHIZHILIAO(WULUNHEZHONGYUANYIN)DEHUANZHEZHONG,CHUXIANLEALTFURANDEHUANZHELISHUJUNJILUZAIBIAO4(JIANXIANGXISHUOMINGSHU)ZHONG。ZHEXIEYANJIUZHONG,RUGUOZAIDI52ZHOUHUOZHIHOUDADAOFANGANSUOGUIDINGDEZHILIAOYINGDAHOU,KEYUNXUYIYAZUHUANZHETINGYAO。RUGUOWEIDADAOZHILIAOYINGDAERTINGYONGENTIKAWEIE,ZETINGYAOHOUFASHENGALTFURANDEGAILVKENENGGENGGAO。A1463038SHUANGMANGYANJIUZHONGGUANCHADAO,HBVHEBINGGANRANHIVDEHUANZHEJIESHOUENTIKAWEI1mg(N=51)HUOANWEIJI(N=17)ZHILIAO24ZHOU,LIANGZUDEANQUANXINGXIANGSI,BINGQIEYUWEIHEBINGGANRANHIVHUANZHEZHONGGUANCHADAODEANQUANXINGXIANGSI(JIAN[JINGGAO]3:HEBINGGANRANHIV)ZAIZHONGGUOJINXINGDELINCHUANGSHIYANZHONG,ZUICHANGJIANDEBULIANGSHIJIANYOU:ALTSHENGGAO、PILAO、XUANYUN、EXIN、FUTONG、FUBUBUSHI、SHANGFUTONG、GANQUBUSHI、JITONG、SHIMIANHEFENGZHEN。ZHEXIEBULIANGSHIJIANDUOWEIQINGDAOZHONGDU。ZAIYULAMIFUDINGDUIZHAODESHIYANZHONG,BENPINBULIANGSHIJIANDEFASHENGLVYULAMIFUDINGXIANGDANG。

斗牛棋牌【ZHUYISHIXIANG】SHENGONGNENGBUQUANDEHUANZHEJIGANQINGCHULV<50ml/min,BAOKUOXUETOUXIHUOCAPDDEHUANZHE,JIANYIDIAOZHENGENTIKAWEIDEGEIYAOJILIANG(JIAN[YONGFAYONGLIANG])。GANYIZHISHOUTIHUANZHEENTIKAWEIZHILIAOGANYIZHISHOUTIDEANQUANXINGHEYOUXIAOXINGSHANGBUQINGCHU。RUGUORENWEIGANYIZHISHOUTIXUYAOJIESHOUENTIKAWEIZHILIAO,QICENGJINGHUOZHENGZAIJIESHOUKENENGYINGXIANGSHENGONGNENGDEMIANYIYIZHI,RUHUANBAOJUNSUHUOTAKEMOSIDEZHILIAO,YINGZAIENTIKAWEIGEIYAOQIANJIGEIYAOGUOCHENGZHONGYANMIJIANCESHENGONGNENG。(JIAN[YAODAIDONGLIXUE])HUANZHEXUZHIHUANZHEYINGZAIYISHENGDEZHIDAOXIAFUYONGENTIKAWEI,BINGGAOZHIYISHENGRENHEXINCHUXIANDEZHENGZHUANGJIHEBINGYONGYAOQINGKUANG。YINGGAOZHIHUANZHERUGUOTINGYAOYOUSHIHUICHUXIANGANZANGBINGQINGJIAZHONG,SUOYIYINGZAIYISHENGDEZHIDAOXIAGAIBIANZHILIAOFANGFA。HUANZHEZAIKAISHIENTIKAWEIZHILIAOQIAN,XUYAOJINXINGHIVKANGTIDEJIANCE。YINGGAOZHIHUANZHERUGUOGANRANLEHIVERWEIJIESHOUYOUXIAODEHIVYAOWUZHILIAO,ENTIKAWEIKENENGHUIZENGJIADUIHIVYAOWUZHILIAONAIYAODEJIHUI(JIAN[JINGGAO]3.HEBINGGANRANHIV)。SHIYONGENTIKAWEIZHILIAOBINGBUNENGJIANGDIJINGXINGJIECHUHUOWURANXUEYUANCHUANBOHBVDEWEIXIANXING。YINCI,XUYAOCAIQUSHIDANGDEFANGHUCUOSHI。

【JINJI】DUIENTIKAWEIHUOZHIJIZHONGRENHECHENGFENGUOMINZHEJINYONG。

【ZHUZANG】MIFENG,ZAI25℃YIXIAGANZAOCHUBAOCUN。

【YOUXIAOQI】18GEYUE

【SHENGCHANCHANGJIA】SUZHOUDONGRUIZHIYAOYOUXIANGONGSI

恩替卡韋分散片的功效與作用

斗牛棋牌ENTIKAWEIFENSANPIANENTIKAWEIFENSANPIANJUYOUBENPINWEIBAISEHUOLEIBAISEPIAN。BAOZHILINDAYAOFANGENTIKAWEIFENSANPIANYEMIANTIGONGSUZHOUDONGRUIZHIYAOYOUXIANGONGSISHENGCHANDEENTIKAWEIFENSANPIAN,ENTIKAWEIFENSANPIANSHUOMINGSHUHANENTIKAWEIFENSANPIANJIAGE、ENTIKAWEIFENSANPIANDEGONGXIAOYUZUOYONG、ENTIKAWEIFENSANPIANDEYONGFAYONGLIANG、ENTIKAWEIFENSANPIANDEFUZUOYONGYUBULIANGFANYING、ENTIKAWEIFENSANPIANDEZHUYISHIXIANGYUJINJIDENGXINXI。

  • 腫瘤用藥
  • 肝膽用藥
  • 神經精神
  • 免疫用藥
  • 胃腸用藥
  • 心腦血管
  • 風濕骨病
  • 泌尿用藥

恩替卡韋分散片的同類產品

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阿德福韋酯片
規格:10mg*14片
恩替卡韋膠囊
規格:0.5mg*7粒
苦參素片
規格:0.1g*24片
秘訣清涼膠囊
規格:0.4g*40粒
恩替卡韋分散片
規格:0.5mg*7片

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HULIANWANGYAOPINXINXIZIGEZHENG: (YUE)--FEIJINGYINGXING--2015--0157 | YUEICPBEI13051054HAO

?2013-2020 GUANGZHOUSHIBAOZHILINYAOYEYOUXIANGONGSI BANQUANSUOYOU

FALVGUWEN:GUANGDONGZHENGDALIANHELVSHISHIWUSUO TEBIESHENGMING:BENZHANNEIRONGJINGONGCANKAO,BUZUOWEIZHENDUANJIYILIAOYIJU。

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